Sweet new publication

November 19, 2017

Sugars and their analogues can be found as antivirals, anticancers and antidiabetic drugs - as well as sweetners, polymers and a host of other useful products.

 

Sugars are pretty simple in some respects - they're made from carbon, hydrogen and oxygen and not much else.  Unfortunately, this also makes them a pain to synthesize: e.g. there are eight diasteriomeric D-hexose sugars (and of their equivalent L-hexoses too!) that vary only by how their alcohol groups are arrayed.  Fortunately, biocatalysis can help - enzymes are great at stereochemistry after all.

 

 

 

 

In our new publication (Hartley et al., 2017), Carol Hartley and coworkers compare cascades of enzymes for the first step of sugar synthesis. 

 

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