Blast from the past

November 15, 2017

In our new publication in Green Chemistry, we've been using ancestral sequence reconstruction, a bioinformatics technique that lets us peer into the past a revive ancient proteins.

 

Using this technique we were able to increase the substrate range of our w-transaminases, providing new biocatalysts and scaffolds for engineering and in vitro evolution.  Ancestral reconstruction has been around for a while, but recent reduction in the cost of DNA synthesis has made it practical as a technique for generating new enzymes.

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