New paper on enzymes that use the strange cofactor F420

May 18, 2017



A nice new publication regarding the cofactor F420-dependent reductases in Frontiers in Microbiology.  This class of enzymes use the reduced form of the unusual cofactor F420 to catalyse the reduction of a wide range of compounds. Despite its structural resemblance to flavins, F420's redox midpoint potential is more like that of NAD (~-420 mV).  As the enzymes can be promiscuous in their substrate ranges, we may be able to use them in biocatalytic applications.


This work was a collaboration between CSIRO and the ANU (A/Prof. Colin Jackson's group) - the lead author, Chris Greening, is now a faculty member at Monash University in Melbourne.

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