A nice new publication regarding the cofactor F420-dependent reductases in Frontiers in Microbiology. This class of enzymes use the reduced form of the unusual cofactor F420 to catalyse the reduction of a wide range of compounds. Despite its structural resemblance to flavins, F420's redox midpoint potential is more like that of NAD (~-420 mV). As the enzymes can be promiscuous in their substrate ranges, we may be able to use them in biocatalytic applications.
This work was a collaboration between CSIRO and the ANU (A/Prof. Colin Jackson's group) - the lead author, Chris Greening, is now a faculty member at Monash University in Melbourne.