Atrazine-degrading enzyme structure published: well on the way to completing the whole pathway!

September 22, 2015

Very happy to share our new publication - "X-ray structure and mutagenesis studies of the N-isopropylammelide isopropylaminohydrolase, AtzC" in PLoS One today...

 

 

 

 

 

 

This paper described the structure and mechanism of the third enzyme in the atrazine catabolic pathway from the soil bacterium Pseudomonas sp. strain ADP - which was isolated about 20 years ago by Lawrence Wackett's lab in Minnesota in the US.

 

It's also the fourth structure from this pathway that we have published as part of a productive (and fun) collaboration with Tom Peat and Janet Newman at CSIRO in Melbourne - and the fifth paper to come from Sahil Balotra's thesis!

 

The picture above shows the AtzC monomer (A), dimer (B) and tetramer C and has been reproduced from the paper in PLoS One.

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